Development of a Multiarray Biosensor for DNA Diagnostics

This work involves the development and evaluation of a multiarray biosensor for DNA diagnostics. The evaluation of various system components developed for the biosensor is discussed. The DNA probes labeled with visible and near infrared (NIR) dyes are evaluated. The detection system uses a two-dimen...

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Veröffentlicht in:	Instrumentation Science and Technology 1998-11, Vol.26 (5), p.503-514
Hauptverfasser:	Vo-Dinh, T., Isola, N., Alarie, J. P., Landis, D., Griffin, G. D., Allison, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	BIODEGRADATION Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES Biomedical engineering Biosensors BIOTECHNOLOGY Charge coupled devices Diagnosis DIAGNOSTIC USES DNA DNA HYBRIDIZATION DNA SEQUENCERS DNA SEQUENCING ENVIRONMENTAL SCIENCES FLUORESCENCE Fundamental and applied biological sciences. Psychology GENES Methods. Procedures. Technologies Oncology Various methods and equipments
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Beschreibung
Zusammenfassung:	This work involves the development and evaluation of a multiarray biosensor for DNA diagnostics. The evaluation of various system components developed for the biosensor is discussed. The DNA probes labeled with visible and near infrared (NIR) dyes are evaluated. The detection system uses a two-dimensional charge-coupled device (CCD). Examples of application of gene probes in DNA hybridization experiments and in biomedical diagnosis (detection of the p53 cancer gene) are presented to illustrate the usefulness and potential of the biosensor device.
ISSN:	1073-9149 1525-6030
DOI:	10.1080/10739149808000917