Stability of methyl p-hydroxybenzoate (methylparaben) to gamma radiolysis

The stability of methyl p-hydroxybenzoate during 60Co γ-radiolysis was studied in the solid state and in 10 μM water solution. The work was undertaken as a model to be extended to radiolytic sterilization of pharmaceutical preparations. Only in water moderate decomposition was observed at high doses...

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Veröffentlicht in:	Radiation physics and chemistry (1993) 1998, Vol.51 (1), p.77-83
Hauptverfasser:	Angelini, Giancarlo, Bucci, Roberto, Colosimo, Marcello, Margonelli, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Aromatic compounds Chemistry Decomposition Exact sciences and technology Gamma rays General and physical chemistry Isotopes Physical chemistry of induced reactions (with radiations, particles and ultrasonics) Radiation chemistry Reaction kinetics Sterilization (cleaning)
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Zusammenfassung:	The stability of methyl p-hydroxybenzoate during 60Co γ-radiolysis was studied in the solid state and in 10 μM water solution. The work was undertaken as a model to be extended to radiolytic sterilization of pharmaceutical preparations. Only in water moderate decomposition was observed at high doses (50 KGy, whilst at 5 kGy sterilization was verified. Methylparaben labelled with carbon-14 on the carboxyl group provided the decomposition yield by the reverse isotope dilution method; mass balances were drawn and mechanisms suggested.
ISSN:	0969-806X 1879-0895
DOI:	10.1016/S0969-806X(97)00104-7