Tetrapyrrolic Glycosylated Macrocycles for an Application in PDT

Tetrapyrrolic Glycosylated Macrocycles for an Application in PDT

The synthesis and characterization of amphiphilic glycoconjugated porphyrins, benzochlorin, and azaporphyrins were reported. Among these molecules, several were found to be efficient photosensitizers in an assay using the human tumoral cell line HT29. Moreover, glycosylated benzochlorin and azaporph...

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Veröffentlicht in:Journal of Biomedical Optics 1999-07, Vol.4 (3), p.298-318
Hauptverfasser: Momenteau, Michel, Maillard, Philippe, De Be´linay, Marie-Anne, Carrez, Danie le, Croisy, Alain
Format: Artikel
Sprache:eng
Schlagworte:
azaporphyrins
benzochlorin
Bioassay
Biosynthesis
Cells
Cytology
glycoconjugated porphyrins
Irradiation
photocytotoxicity
Photosensitizers
Porphyrins
synthesis
Toxicity
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Beschreibung
Zusammenfassung:The synthesis and characterization of amphiphilic glycoconjugated porphyrins, benzochlorin, and azaporphyrins were reported. Among these molecules, several were found to be efficient photosensitizers in an assay using the human tumoral cell line HT29. Moreover, glycosylated benzochlorin and azaporphyrins, whose absorption bands in the red region of the visible spectrum are substantially increased as compared to porphyrins, display a good photocytotoxicity on tumor cells after irradiation with wavelength above 590 nm. ©
ISSN:1083-3668
1560-2281
DOI:10.1117/1.429932