Advances in the Application of Modified Nucleotides in SELEX Technology

Aptamers are widely used as molecular recognition elements for detecting and blocking functional biological molecules. Since the common “alphabet” of DNA and RNA consists of only four letters, the chemical diversity of aptamers is less than the diversity of protein recognition elements built of 20 a...

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Veröffentlicht in:	Biochemistry (Moscow) 2018-10, Vol.83 (10), p.1161-1172
Hauptverfasser:	Antipova, O. M., Zavyalova, E. G., Golovin, A. V., Pavlova, G. V., Kopylov, A. M., Reshetnikov, R. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - chemistry Antibodies Aptamers Aptamers, Nucleotide - chemistry Base Pairing Biochemistry Bioengineering Biological research Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Chemical modification Click Chemistry Deoxyribonucleic acid Deoxyribose - chemistry DNA Evolution Innovations Life Sciences Ligands Ligands (Biochemistry) Microbiology Nucleotidases - chemistry Nucleotides Oligonucleotides - chemistry Organic chemistry Polymerase chain reaction Proteins Recognition Review Ribonucleic acid RNA RNA polymerase SELEX Aptamer Technique
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Beschreibung
Zusammenfassung:	Aptamers are widely used as molecular recognition elements for detecting and blocking functional biological molecules. Since the common “alphabet” of DNA and RNA consists of only four letters, the chemical diversity of aptamers is less than the diversity of protein recognition elements built of 20 amino acids. Chemical modification of nucleotides enlarges the potential of DNA/RNA aptamers. This review describes the latest achievements in a variety of approaches to aptamers selection with an extended genetic alphabet.
ISSN:	0006-2979 1608-3040
DOI:	10.1134/S0006297918100024