Relative Telomere Length and Stroke Risk in a Chinese Han Population

Relative Telomere Length and Stroke Risk in a Chinese Han Population

This study aimed to further understand the role of relative telomere length (RTL) in susceptibility to stroke and investigate the association regulator of telomere elongation helicase 1 ( RETL1 ) gene polymorphisms and RTL. RTL was measured using the real-time quantitative polymerase chain reaction...

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Veröffentlicht in:Journal of molecular neuroscience 2018-12, Vol.66 (4), p.475-481
Hauptverfasser: Gao, Dan, Zhang, Rui, Ji, Guofa, Li, Chunqi, Guo, Dangshe, Jin, Tianbo, Chen, Mingwei
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biomedical and Life Sciences
Biomedicine
Cell Biology
China
Confidence intervals
DNA helicase
DNA Helicases - genetics
Elongation
Female
Genotypes
Genotyping
Health risks
Humans
Male
Middle Aged
Neurochemistry
Neurology
Neurosciences
Patients
Polymerase chain reaction
Polymorphism, Single Nucleotide
Population studies
Proteomics
Risk
Stroke
Stroke - genetics
Telomere - genetics
Telomere Homeostasis
Telomeres
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Zusammenfassung:This study aimed to further understand the role of relative telomere length (RTL) in susceptibility to stroke and investigate the association regulator of telomere elongation helicase 1 ( RETL1 ) gene polymorphisms and RTL. RTL was measured using the real-time quantitative polymerase chain reaction (qPCR) from 300 stroke patients and 299 healthy controls. Genotyping was performed using the Sequenom MassARRAY platform. The results indicated that stroke patients had significantly shorter median RTL than controls ( P  
ISSN:0895-8696
1559-1166
DOI:10.1007/s12031-018-1160-9