Recent advances of the Povarov reaction in medicinal chemistry

[Display omitted] The Povarov multicomponent reaction consists on the condensation of an aniline, an aldehyde, and an activated olefin to generate a tetrahydroquinoline adduct with 3 diversity points. Hereby, we report the main features of this transformation and its uses in medicinal chemistry. Rel...

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Veröffentlicht in:	Drug discovery today. Technologies 2018-11, Vol.29, p.71-79
Hauptverfasser:	Ghashghaei, Ouldouz, Masdeu, Carme, Alonso, Concepción, Palacios, Francisco, Lavilla, Rodolfo
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes - chemistry Alkenes - chemistry Aniline Compounds - chemistry Anti-Infective Agents - chemical synthesis Antineoplastic Agents - chemical synthesis Catalysis Chemistry, Pharmaceutical - methods Drug Discovery - methods Neurotransmitter Agents - chemical synthesis Quinolines - chemical synthesis Stereoisomerism
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Zusammenfassung:	[Display omitted] The Povarov multicomponent reaction consists on the condensation of an aniline, an aldehyde, and an activated olefin to generate a tetrahydroquinoline adduct with 3 diversity points. Hereby, we report the main features of this transformation and its uses in medicinal chemistry. Relevant examples of the impact of Povarov adducts in different therapeutic areas are provided.
ISSN:	1740-6749 1740-6749
DOI:	10.1016/j.ddtec.2018.08.004