Phosphatidylinositol 3-Kinase, Growth Disorders, and Cancer

Phosphatidylinositol 3-kinase (PI3K) is involved in multiple cell processes, including insulin signaling, cell growth, immunity, and brain development. It is activated in a wide variety of cancers and is being targeted as a treatment, with notable success in lymphoma.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-11, Vol.379 (21), p.2052-2062
Hauptverfasser:	Goncalves, Marcus D, Hopkins, Benjamin D, Cantley, Lewis C
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adapter proteins Animals Cancer Cancer therapies Cell cycle Cell division Cell growth Cell Proliferation - physiology Diabetes Diet Evolution, Molecular Feedback Growth Disorders - metabolism Growth factors Humans Hyperglycemia Insulin Insulin resistance Kinases Lipids Lymphoma Metabolism Neoplasms - drug therapy Neoplasms - metabolism Oncogenes - physiology Phosphatidylinositol 3-Kinase - physiology Phosphatidylinositols - chemistry Phosphoinositide-3 Kinase Inhibitors Signal transduction Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	Phosphatidylinositol 3-kinase (PI3K) is involved in multiple cell processes, including insulin signaling, cell growth, immunity, and brain development. It is activated in a wide variety of cancers and is being targeted as a treatment, with notable success in lymphoma.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMra1704560