Link between von Willebrand factor multimers, relapses and coronary microcirculation in patients with thrombotic thrombocytopenic purpura in remission

Link between von Willebrand factor multimers, relapses and coronary microcirculation in patients with thrombotic thrombocytopenic purpura in remission

ADAMTS13 deficiency results in unusually large von Willebrand factor (ULVWF) multimers in the circulation and a higher risk of microthrombi due to high shear stress. In patients treated for acquired thrombotic thrombocytopenic purpura (TTP), a persistently severe ADAMTS13 deficiency (

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Veröffentlicht in:Thrombosis research 2019-01, Vol.173, p.42-47
Hauptverfasser: Di Pasquale, Irene, Budde, Ulrich, Tona, Francesco, Bertomoro, Antonella, Lombardi, Anna Maria, Famoso, Giulia, Bertozzi, Irene, Dittmer, Rita, Schneppenheim, Sonja, Fabris, Fabrizio
Format: Artikel
Sprache:eng
Schlagworte:
ADAMTS13
Thrombotic thrombocytopenic purpura (TTP)
von Willebrand factor
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Zusammenfassung:ADAMTS13 deficiency results in unusually large von Willebrand factor (ULVWF) multimers in the circulation and a higher risk of microthrombi due to high shear stress. In patients treated for acquired thrombotic thrombocytopenic purpura (TTP), a persistently severe ADAMTS13 deficiency (
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2018.11.005