Electrochemical Oxidation with Lewis-Acid Catalysis Leads to Trifluoromethylative Difunctionalization of Alkenes Using CF3SO2Na

Electrochemical Oxidation with Lewis-Acid Catalysis Leads to Trifluoromethylative Difunctionalization of Alkenes Using CF3SO2Na

The directly external oxidant-free oxytrifluoromethylation and aminotrifluoromethylation of alkenes have been developed through the constant current electrolysis synergizing with a Lewis-acid catalysis protocol. By using sodium trifluoromethanesulfinate as the trifluoromethyl source, the method enab...

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Veröffentlicht in:Organic letters 2018-12, Vol.20 (23), p.7396-7399
Hauptverfasser: Zhang, Lingling, Zhang, Guoting, Wang, Pan, Li, Yongli, Lei, Aiwen
Format: Artikel
Sprache:eng
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Zusammenfassung:The directly external oxidant-free oxytrifluoromethylation and aminotrifluoromethylation of alkenes have been developed through the constant current electrolysis synergizing with a Lewis-acid catalysis protocol. By using sodium trifluoromethanesulfinate as the trifluoromethyl source, the method enabled difunctionalization of C–C double bonds of a wide range of styrene derivatives.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b03081