Efficacy and safety of treatment of hyposecretory dry eye with platelet‐rich plasma

Objective To evaluate and compare the symptomatology and clinical findings in hyposecretory dry eye of the treatment with platelet‐rich plasma (PRP) and artificial tears of sodium hyaluronate (SH). Methods Blind single‐centre prospective comparative randomized study including 83 patients with hyposecretory dry eye and mean age of 64.0 years. Two groups were differentiated depending on the treatment applied: 44 patients treated with PRP (PRP group), and 39 patients treated with artificial tears of SH (SH group). Changes in Schimer test, tear osmolarity, corneal and conjunctival staining, tear film break‐up time (TF‐BUT), conjunctival hyperaemia, dry eye‐related symptoms with the Ocular Surface Disease Index questionnaire, and caliciform cell density were evaluated during 30 days of treatment. Results Significantly larger reduction in symptomatology (p