Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

A new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepare...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-11, Vol.54 (95), p.13455-13458
Hauptverfasser: Revuelta, Julia, Fuentes, Roberto, Lagartera, Laura, Hernáiz, María José, Bastida, Agatha, García-Junceda, Eduardo, Fernández-Mayoralas, Alfonso
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container_issue 95
container_start_page 13455
container_title Chemical communications (Cambridge, England)
container_volume 54
creator Revuelta, Julia
Fuentes, Roberto
Lagartera, Laura
Hernáiz, María José
Bastida, Agatha
García-Junceda, Eduardo
Fernández-Mayoralas, Alfonso
description A new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepared and their interaction with the FGF2 protein was analyzed.
doi_str_mv 10.1039/c8cc08067d
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title Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics
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