Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

A new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepare...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-11, Vol.54 (95), p.13455-13458
Hauptverfasser: Revuelta, Julia, Fuentes, Roberto, Lagartera, Laura, Hernáiz, María José, Bastida, Agatha, García-Junceda, Eduardo, Fernández-Mayoralas, Alfonso
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Sprache:eng
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Zusammenfassung:A new strategy that enables a modular straightforward synthesis of heparan sulfate oligosaccharide mimics by the assembly of simple glycoamino acid building blocks is described. The coupling between units is readily carried out by an amidation reaction. Several glycoamino acid oligomers were prepared and their interaction with the FGF2 protein was analyzed.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc08067d