Pulmonary arterial hypertension associated with interferon beta treatment for multiple sclerosis: a case report

A 23-year-old woman with multiple sclerosis developed respiratory symptoms 3 years after introduction of interferon beta-1b. The diagnosis of pulmonary arterial hypertension (PAH) was established. The patient partially responded to sildenafil and bosetan treatment. This is the first report of PAH, a...

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Veröffentlicht in:	Multiple sclerosis 2009-07, Vol.15 (7), p.885-886
Hauptverfasser:	Ledinek, AH, Jazbec, SŠ, Drinovec, I, Rot, U
Format:	Artikel
Sprache:	eng
Schlagworte:	Antihypertensive Agents - therapeutic use Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug Therapy, Combination Female Hemodynamics - drug effects Humans Hypertension, Pulmonary - chemically induced Hypertension, Pulmonary - drug therapy Hypertension, Pulmonary - physiopathology Immunologic Factors - adverse effects Interferon beta-1b Interferon-beta - adverse effects Medical sciences Multiple Sclerosis - drug therapy Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Neurology Piperazines - therapeutic use Pulmonary Artery - drug effects Pulmonary Artery - physiopathology Purines - therapeutic use Sildenafil Citrate Sulfonamides - therapeutic use Sulfones - therapeutic use Treatment Outcome Young Adult
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Zusammenfassung:	A 23-year-old woman with multiple sclerosis developed respiratory symptoms 3 years after introduction of interferon beta-1b. The diagnosis of pulmonary arterial hypertension (PAH) was established. The patient partially responded to sildenafil and bosetan treatment. This is the first report of PAH, associated with interferon beta therapy. As shown in experimental models, interferon treatment can induce PAH by stimulation of thromboxane cascade and secretion of various inflammatory mediators.
ISSN:	1352-4585 1477-0970
DOI:	10.1177/1352458509104593