Synthesis of fluoroalkylated alkynes via visible-light photocatalysis

Synthesis of fluoroalkylated alkynes via visible-light photocatalysis

Fluoroalkylated alkynes, which are versatile building blocks for the synthesis of various biologically active organofluorine compounds, were synthesized from easily available alkynyl halides and fluoroalkyl halides by visible-light photocatalysis. Addition of fluoroalkyl radicals to alkynes and subs...

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Veröffentlicht in:Organic & biomolecular chemistry 2019-02, Vol.17 (7), p.1758-1762
Hauptverfasser: Iqbal, Naila, Iqbal, Naeem, Han, Sung Su, Cho, Eun Jin
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Biological activity
Dehalogenation
Halides
NMR
Nuclear magnetic resonance
Organofluorine compounds
Photocatalysis
Synthesis
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Zusammenfassung:Fluoroalkylated alkynes, which are versatile building blocks for the synthesis of various biologically active organofluorine compounds, were synthesized from easily available alkynyl halides and fluoroalkyl halides by visible-light photocatalysis. Addition of fluoroalkyl radicals to alkynes and subsequent dehalogenation selectively yielded fluoroalkylated alkynes.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02486c