Biosynthesis of Erythromycin and Rapamycin

Biosynthesis of Erythromycin and Rapamycin

Staunton and Wilkinson consider the biosynthesis of erythromycin and rapamycin, macrolide antibiotics. Erythromycin and rapamycin are the most thoroughly researched aliphatic polyketides at the genetic level.

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Veröffentlicht in:Chemical reviews 1997-11, Vol.97 (7), p.2611-2630
Hauptverfasser: Staunton, James, Wilkinson, Barrie
Format: Artikel
Sprache:eng
Schlagworte:
Antibiotics
Enzymes
Genetics
Molecular biology
Nuclear magnetic resonance spectroscopy
Organic chemistry
Polypeptides
Structure (composition)
X ray crystallography
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Beschreibung
Zusammenfassung:Staunton and Wilkinson consider the biosynthesis of erythromycin and rapamycin, macrolide antibiotics. Erythromycin and rapamycin are the most thoroughly researched aliphatic polyketides at the genetic level.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr9600316