Effects of prenatal and neonatal cadmium intoxication on the intensity of lipid peroxidation and activity of glutathione system in progeny of albino rats

Oral treatment of pregnant or lactating rats with Cd(NO₃)₂ in a dose of 2 mg/kg increased plasma and erythrocyte levels of MDA and reduced glutathione, activities of glutathione-S-transferase, glutathione reductase, and γ-glutamyl transferase in their 4-month-old progeny. Changes in the function of...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2008-07, Vol.146 (1), p.41-44
Hauptverfasser:	Slyuzova, O. V, Stepanova, E. V, Temraleeva, A. D, Kireev, R. A, Ignatov, V. V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Biophysics and Biochemistry cadmium Cadmium - toxicity Cell Biology erythrocytes Female Fetus - drug effects gamma-Glutamyltransferase - metabolism Glutathione - metabolism Glutathione Reductase - metabolism glutathione system Glutathione Transferase - metabolism Internal Medicine Laboratory Medicine lipid peroxidation Lipid Peroxidation - drug effects Malondialdehyde - blood Pathology plasma Pregnancy Rats
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Zusammenfassung:	Oral treatment of pregnant or lactating rats with Cd(NO₃)₂ in a dose of 2 mg/kg increased plasma and erythrocyte levels of MDA and reduced glutathione, activities of glutathione-S-transferase, glutathione reductase, and γ-glutamyl transferase in their 4-month-old progeny. Changes in the function of glutathione system and LPO intensity after cadmium intoxication during the neonatal were less pronounced than after prenatal exposure.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-008-0230-3