A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

A Viedma ripening route to an enantiopure building block for Levetiracetam and Brivaracetam

A simple route to enantiomerically pure (S)-2-aminobutyramide - the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is de...

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Veröffentlicht in:Organic & biomolecular chemistry 2019, Vol.17 (1), p.35-38
Hauptverfasser: Baglai, Iaroslav, Leeman, Michel, Kellogg, Richard M, Noorduin, Willem L
Format: Artikel
Sprache:eng
Schlagworte:
Epilepsy
Etiracetam
Ripening
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Zusammenfassung:A simple route to enantiomerically pure (S)-2-aminobutyramide - the chiral component of the anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is based on the rational design and application of a Viedma ripening process. The practical potential of the process is demonstrated on a large scale.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02660b