Neuroprotective Effects of Dibornol in Focal Cerebral Ischemia/Reperfusion in Rats

Neuroprotective activity of 2,6-diisobornyl-4-methylphenol (Dibornol) was studied under conditions of experimental focal cerebral ischemia/reperfusion modeled by intraluminal occlusion of the left middle cerebral artery for 1 h followed by recirculation. Dibornol administered in a dose of 10 mg/kg i...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2018-11, Vol.166 (1), p.15-18
Hauptverfasser:	Chenysheva, G. A., Smol’akova, V. A., Kutchin, A. V., Chukicheva, I. Yu, Plotnikov, M. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedical and Life Sciences Biomedicine Bornanes - therapeutic use Brain - drug effects Brain - pathology Brain Infarction - drug therapy Brain Ischemia - drug therapy Cell Biology Cerebral blood flow Cerebral infarction Cresols - therapeutic use Internal Medicine Ischemia Laboratory Medicine Male Neuroprotection Neuroprotective Agents - therapeutic use Pathology Rats Rats, Wistar Reperfusion Reperfusion Injury - drug therapy Rodents
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Zusammenfassung:	Neuroprotective activity of 2,6-diisobornyl-4-methylphenol (Dibornol) was studied under conditions of experimental focal cerebral ischemia/reperfusion modeled by intraluminal occlusion of the left middle cerebral artery for 1 h followed by recirculation. Dibornol administered in a dose of 10 mg/kg intragastrically 24 h and 30 min before and 24 h after focal ischemia/reperfusion modeling reduced the size of the brain infarction zone by 52% (48 h after recirculation) and neurological deficit by 1.7-2.4 times in comparison with that in control animals.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-018-4278-4