comparative analysis of the molecular genetic processes in the pathogenesis of psoriasis and Crohn's disease

A comparative bioinformatics analysis of the molecular genetic processes in the pathogenesis of multifactorial diseases--psoriasis and Crohn's disease--was performed using the results of microarray experiments deposited with the GEO DataSets database. A number of genes and molecular genetic processes common to both pathologies were found. The involvement of several transcription factors, including AP-1 transcription factors, in the pathogeneses of both psoriasis and Crohn's disease was postulated.