Selection strategies for anticancer antibody discovery: searching off the beaten path

Highlights • There is a paucity of tumor-associated antigens for antibody targeting in oncology. • Phage antibody libraries are available for the generation of therapeutic antibodies. • Advanced selection conditions allow ex vivo selection of anticancer antibodies. • There is no technology for antig...

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Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2015-05, Vol.33 (5), p.292-301
Hauptverfasser:	Sánchez-Martín, David, Sørensen, Morten Dræby, Lykkemark, Simon, Sanz, Laura, Kristensen, Peter, Ruoslahti, Erkki, Álvarez-Vallina, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced phage selections Animals antibodies Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - therapeutic use Antibodies, Neoplasm - chemistry Antibodies, Neoplasm - therapeutic use antigens Antigens, Neoplasm - chemistry Antineoplastic Agents - chemistry Antineoplastic Agents - therapeutic use bacteriophages Cancer Cell Surface Display Techniques Drug Discovery drugs Epidermal growth factor Humans Hypoxia Internal Medicine Medical Oncology - trends neoplasms Neoplasms - immunology Neoplasms - therapy phage display Pharmacokinetics therapeutic antibodies therapeutics Tumor Microenvironment tumor-associated antigens Tumors Vascular endothelial growth factor
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Beschreibung
Zusammenfassung:	Highlights • There is a paucity of tumor-associated antigens for antibody targeting in oncology. • Phage antibody libraries are available for the generation of therapeutic antibodies. • Advanced selection conditions allow ex vivo selection of anticancer antibodies. • There is no technology for antigen profiling of intact tumors • Sequential ex vivo and in vivo phage selection allows the selection of tumor-homing antibodies.
ISSN:	0167-7799 1879-3096
DOI:	10.1016/j.tibtech.2015.02.008