Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia

This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive...

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Veröffentlicht in:	Biochemistry (Moscow) 2008-11, Vol.73 (11), p.1171-1175
Hauptverfasser:	Isaev, N. K, Stelmashook, E. V, Plotnikov, E. Y, Khryapenkova, T. G, Lozier, E. R, Doludin, Y. V, Silachev, D. N, Zorov, D. B
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Sensing Ion Channels Acidosis - metabolism Acidosis - physiopathology Animals Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Brain damage Brain Ischemia - metabolism Brain Ischemia - physiopathology Cell Death Glutamic Acid - metabolism Glutamic Acid - toxicity Humans Hypoxia Hypoxia - metabolism Hypoxia - physiopathology Life Sciences Microbiology Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Neurons Neurons - cytology Neurons - drug effects Neurons - physiology Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Review Sodium Channels - genetics Sodium Channels - metabolism
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Zusammenfassung:	This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.
ISSN:	0006-2979 1608-3040
DOI:	10.1134/s0006297908110011