Formulation and evaluation of diclofenac sodium delayed release tablets

Formulation and evaluation of diclofenac sodium delayed release tablets

Delayed release tablets of Diclofenac sodium tablets were prepared by wet granulation method using different pH resistant polymers like HPMC, CAP and Eudragit to dissolve it in alkaline pH. F1-F4 trials were performed and evaluated. F4 was found to be satisfactory. F4 was seal coated using HPMC E-5...

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Veröffentlicht in:Biosciences, biotechnology research Asia biotechnology research Asia, 2009-12, Vol.6 (2), p.703-708
Hauptverfasser: Ravichandiran, V, Masilamani, K, Senthilnathan, B, Umadevi, S K, Padmapriya, S, Saraswathy, T, Kumar, YDN
Format: Artikel
Sprache:eng
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Zusammenfassung:Delayed release tablets of Diclofenac sodium tablets were prepared by wet granulation method using different pH resistant polymers like HPMC, CAP and Eudragit to dissolve it in alkaline pH. F1-F4 trials were performed and evaluated. F4 was found to be satisfactory. F4 was seal coated using HPMC E-5 EP & PEG 400L(F5). F5 was enteric coated using HPMC(F6-F7), CAP(F8-F9), EUDRAGIT(F10-F11). Dissolution was carried out in 0.1 N HCI for first 2hrs and next 1hr in phosphate buffer pH6.8. Dissolution studies of EUDRAGIT polymer trail (F10) shows much better release then HPMC and CAP.
ISSN:0973-1245