One-step construction of molecular complexity by tert-butyl nitrite (TBN)-initiated cascade α,β-sp3 C–H bond difunctionalization and C–N bond cleavage

One-step construction of molecular complexity by tert-butyl nitrite (TBN)-initiated cascade α,β-sp3 C–H bond difunctionalization and C–N bond cleavage

TBN-initiated cascade multifunctionalization of inert C–H and C–N bonds in N-arylazacycles has been realized under transition-metal free conditions, in which the synthetically useful oxime, N–NO and aldehyde functional groups were constructed in only one synthetic step.

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018-11, Vol.54 (94), p.13232-13235
Hauptverfasser: He, Kaixuan, Li, Pengfei, Zhang, Shuwei, Chen, Qian, Ji, Honghe, Yu, Yuan, Jia, Xiaodong
Format: Artikel
Sprache:eng
Schlagworte:
Crystallography
Functional groups
Hydrogen bonds
Transition metals
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Beschreibung
Zusammenfassung:TBN-initiated cascade multifunctionalization of inert C–H and C–N bonds in N-arylazacycles has been realized under transition-metal free conditions, in which the synthetically useful oxime, N–NO and aldehyde functional groups were constructed in only one synthetic step.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc06946h