Paracrine effect of mesenchymal stem cell as a novel therapeutic strategy for diabetic nephropathy
Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the main reason for end-stage renal diseases (ESRD). Based on the role of mesenchymal stem cells (MSCs) in regenerative medicine, the MSC therapy has been considered a promising strategy to ameliorate the progres...
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| Veröffentlicht in: | Life sciences (1973) 2018-12, Vol.215, p.113-118 |
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| container_title | Life sciences (1973) |
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| creator | Li, Hongde Rong, Pengfei Ma, Xiaoqian Nie, Wei Chen, Cheng Yang, Cejun Zhang, Juan Dong, Qiong Wang, Wei |
| description | Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the main reason for end-stage renal diseases (ESRD). Based on the role of mesenchymal stem cells (MSCs) in regenerative medicine, the MSC therapy has been considered a promising strategy to ameliorate the progression of DN. In this article, we review the therapeutic potential of MSCs in DN, mainly involving MSC paracrine mechanism based on trophic factors and extracellular vesicles. Knowledge of mechanism underlying the therapeutic action of MSCs on DN can provide much needed new drug targets for this disease.
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| doi_str_mv | 10.1016/j.lfs.2018.11.001 |
| format | Article |
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[Display omitted]</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2018.11.001</identifier><identifier>PMID: 30399376</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Diabetic Nephropathies - physiopathology ; Diabetic Nephropathies - therapy ; Diabetic nephropathy ; Disease Progression ; Humans ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - therapy ; Mesenchymal Stem Cell Transplantation - methods ; Mesenchymal stem cells ; Mesenchymal Stem Cells - cytology ; Paracrine ; Paracrine Communication - physiology ; Regenerative medicine ; Regenerative Medicine - methods</subject><ispartof>Life sciences (1973), 2018-12, Vol.215, p.113-118</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1f098c859e1f10268d9fef69cff78abd400e1792c9552e5440b76759eca82c533</citedby><cites>FETCH-LOGICAL-c353t-1f098c859e1f10268d9fef69cff78abd400e1792c9552e5440b76759eca82c533</cites><orcidid>0000-0001-6853-7785 ; 0000-0002-2497-1851</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0024320518307069$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30399376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Hongde</creatorcontrib><creatorcontrib>Rong, Pengfei</creatorcontrib><creatorcontrib>Ma, Xiaoqian</creatorcontrib><creatorcontrib>Nie, Wei</creatorcontrib><creatorcontrib>Chen, Cheng</creatorcontrib><creatorcontrib>Yang, Cejun</creatorcontrib><creatorcontrib>Zhang, Juan</creatorcontrib><creatorcontrib>Dong, Qiong</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><title>Paracrine effect of mesenchymal stem cell as a novel therapeutic strategy for diabetic nephropathy</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the main reason for end-stage renal diseases (ESRD). Based on the role of mesenchymal stem cells (MSCs) in regenerative medicine, the MSC therapy has been considered a promising strategy to ameliorate the progression of DN. In this article, we review the therapeutic potential of MSCs in DN, mainly involving MSC paracrine mechanism based on trophic factors and extracellular vesicles. Knowledge of mechanism underlying the therapeutic action of MSCs on DN can provide much needed new drug targets for this disease.
[Display omitted]</description><subject>Animals</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic Nephropathies - therapy</subject><subject>Diabetic nephropathy</subject><subject>Disease Progression</subject><subject>Humans</subject><subject>Kidney Failure, Chronic - etiology</subject><subject>Kidney Failure, Chronic - physiopathology</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Mesenchymal Stem Cell Transplantation - methods</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Paracrine</subject><subject>Paracrine Communication - physiology</subject><subject>Regenerative medicine</subject><subject>Regenerative Medicine - methods</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVoiB0nPyCXomMvu51ZWbsreiqmTQqB9pCchVY7imX2q9La4H8fGbs59jQwPO_LzMPYA0KOgOXXXd65mBeAdY6YA-AVW2JdqQxKgZ_YEqBYZ6IAuWC3Me4AQMpK3LCFAKGUqMola_6YYGzwA3FyjuzMR8d7ijTY7bE3HY8z9dxS13ETueHDeKCOz1sKZqL97G0Cgpnp7cjdGHjrTUOn7UDTNoyTmbfHO3btTBfp_jJX7PXnj5fNU_b8-_HX5vtzZoUUc4YOVG1rqQgdQlHWrXLkSmWdq2rTtGsAwkoVVklZkFyvoanKKuHW1IWVQqzYl3PvFMa_e4qz7n08XW4GGvdRFyigBqjS8yuGZ9SGMcZATk_B9yYcNYI-qdU7ndTqk1qNqJPalPl8qd83PbUfiX8uE_DtDFB68uAp6Gh98kitD0msbkf_n_p37eGKMg</recordid><startdate>20181215</startdate><enddate>20181215</enddate><creator>Li, Hongde</creator><creator>Rong, Pengfei</creator><creator>Ma, Xiaoqian</creator><creator>Nie, Wei</creator><creator>Chen, Cheng</creator><creator>Yang, Cejun</creator><creator>Zhang, Juan</creator><creator>Dong, Qiong</creator><creator>Wang, Wei</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6853-7785</orcidid><orcidid>https://orcid.org/0000-0002-2497-1851</orcidid></search><sort><creationdate>20181215</creationdate><title>Paracrine effect of mesenchymal stem cell as a novel therapeutic strategy for diabetic nephropathy</title><author>Li, Hongde ; Rong, Pengfei ; Ma, Xiaoqian ; Nie, Wei ; Chen, Cheng ; Yang, Cejun ; Zhang, Juan ; Dong, Qiong ; Wang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1f098c859e1f10268d9fef69cff78abd400e1792c9552e5440b76759eca82c533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diabetic Nephropathies - therapy</topic><topic>Diabetic nephropathy</topic><topic>Disease Progression</topic><topic>Humans</topic><topic>Kidney Failure, Chronic - etiology</topic><topic>Kidney Failure, Chronic - physiopathology</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Mesenchymal Stem Cell Transplantation - methods</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal Stem Cells - cytology</topic><topic>Paracrine</topic><topic>Paracrine Communication - physiology</topic><topic>Regenerative medicine</topic><topic>Regenerative Medicine - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Hongde</creatorcontrib><creatorcontrib>Rong, Pengfei</creatorcontrib><creatorcontrib>Ma, Xiaoqian</creatorcontrib><creatorcontrib>Nie, Wei</creatorcontrib><creatorcontrib>Chen, Cheng</creatorcontrib><creatorcontrib>Yang, Cejun</creatorcontrib><creatorcontrib>Zhang, Juan</creatorcontrib><creatorcontrib>Dong, Qiong</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Hongde</au><au>Rong, Pengfei</au><au>Ma, Xiaoqian</au><au>Nie, Wei</au><au>Chen, Cheng</au><au>Yang, Cejun</au><au>Zhang, Juan</au><au>Dong, Qiong</au><au>Wang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Paracrine effect of mesenchymal stem cell as a novel therapeutic strategy for diabetic nephropathy</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2018-12-15</date><risdate>2018</risdate><volume>215</volume><spage>113</spage><epage>118</epage><pages>113-118</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the main reason for end-stage renal diseases (ESRD). Based on the role of mesenchymal stem cells (MSCs) in regenerative medicine, the MSC therapy has been considered a promising strategy to ameliorate the progression of DN. In this article, we review the therapeutic potential of MSCs in DN, mainly involving MSC paracrine mechanism based on trophic factors and extracellular vesicles. Knowledge of mechanism underlying the therapeutic action of MSCs on DN can provide much needed new drug targets for this disease.
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| fulltext | fulltext |
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| ispartof | Life sciences (1973), 2018-12, Vol.215, p.113-118 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Diabetic Nephropathies - physiopathology Diabetic Nephropathies - therapy Diabetic nephropathy Disease Progression Humans Kidney Failure, Chronic - etiology Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stem Cells - cytology Paracrine Paracrine Communication - physiology Regenerative medicine Regenerative Medicine - methods |
| title | Paracrine effect of mesenchymal stem cell as a novel therapeutic strategy for diabetic nephropathy |
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