Paracrine effect of mesenchymal stem cell as a novel therapeutic strategy for diabetic nephropathy

Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the main reason for end-stage renal diseases (ESRD). Based on the role of mesenchymal stem cells (MSCs) in regenerative medicine, the MSC therapy has been considered a promising strategy to ameliorate the progres...

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Veröffentlicht in:	Life sciences (1973) 2018-12, Vol.215, p.113-118
Hauptverfasser:	Li, Hongde, Rong, Pengfei, Ma, Xiaoqian, Nie, Wei, Chen, Cheng, Yang, Cejun, Zhang, Juan, Dong, Qiong, Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetic Nephropathies - physiopathology Diabetic Nephropathies - therapy Diabetic nephropathy Disease Progression Humans Kidney Failure, Chronic - etiology Kidney Failure, Chronic - physiopathology Kidney Failure, Chronic - therapy Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stem Cells - cytology Paracrine Paracrine Communication - physiology Regenerative medicine Regenerative Medicine - methods
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Zusammenfassung:	Diabetic nephropathy (DN) is a microvascular complication of diabetes mellitus (DM) and the main reason for end-stage renal diseases (ESRD). Based on the role of mesenchymal stem cells (MSCs) in regenerative medicine, the MSC therapy has been considered a promising strategy to ameliorate the progression of DN. In this article, we review the therapeutic potential of MSCs in DN, mainly involving MSC paracrine mechanism based on trophic factors and extracellular vesicles. Knowledge of mechanism underlying the therapeutic action of MSCs on DN can provide much needed new drug targets for this disease. [Display omitted]
ISSN:	0024-3205 1879-0631
DOI:	10.1016/j.lfs.2018.11.001