Guided antibiotic therapy for Mycoplasma genitalium infections: Analysis of mutations associated with resistance to macrolides and fluoroquinolones
The objective of this study was to analyse the susceptibility of Mycoplasma genitalium to macrolides and fluoroquinolones using molecular techniques. Susceptibility to macrolides was tested (Gipuzkoa, 2014-2017) by a rapid probe-based real-time polymerase chain reaction assay (23S rRNA gene) and to...
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| Veröffentlicht in: | Enfermedades infecciosas y microbiologia clinica 2019-06, Vol.37 (6), p.394-397 |
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| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng ; spa |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The objective of this study was to analyse the susceptibility of Mycoplasma genitalium to macrolides and fluoroquinolones using molecular techniques.
Susceptibility to macrolides was tested (Gipuzkoa, 2014-2017) by a rapid probe-based real-time polymerase chain reaction assay (23S rRNA gene) and to fluoroquinolones by sequencing the parC and gyrA genes.
Mutations associated with macrolide resistance were detected in 43/263 (16.3%) cases and potential fluoroquinolone resistance in 21/267 (7.9%). Macrolide resistance was more frequent in patients previously treated with azithromycin (76.5% vs 7.4%, P |
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| ISSN: | 1578-1852 2529-993X |
| DOI: | 10.1016/j.eimc.2018.10.003 |