Palladium-Catalyzed Carbon Isotope Exchange on Aliphatic and Benzoic Acid Chlorides

Palladium-Catalyzed Carbon Isotope Exchange on Aliphatic and Benzoic Acid Chlorides

An operationally simple protocol for a palladium-catalyzed 13CO and 14CO exchange with activated aliphatic and benzoic carbonyls is presented. Several 13C and 14C building blocks, natural product derivatives, and pharmaceuticals have been prepared to showcase the method for late-stage carbon isotope...

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Veröffentlicht in:Journal of the American Chemical Society 2018-11, Vol.140 (46), p.15596-15600
Hauptverfasser: Gauthier, Donald R, Rivera, Nelo R, Yang, Haifeng, Schultz, Danielle M, Shultz, C. Scott
Format: Artikel
Sprache:eng
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Zusammenfassung:An operationally simple protocol for a palladium-catalyzed 13CO and 14CO exchange with activated aliphatic and benzoic carbonyls is presented. Several 13C and 14C building blocks, natural product derivatives, and pharmaceuticals have been prepared to showcase the method for late-stage carbon isotope incorporation and its functional group compatibility.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b09808