Atrazine Exposure Decreases Cell Proliferation in Chinese Hamster Ovary (CHO-K1) Cell Line

The aim of this study was to determine the toxic effect of atrazine at the ovarian cellular level. Chinese Hamster Ovary (CHO-K1) cell line was used to evaluate the degree of in vitro atrazine cytotoxicity and the morphological changes were followed during the cell death. Application of four bioassa...

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Veröffentlicht in:	Bulletin of environmental contamination and toxicology 2008-08, Vol.81 (2), p.205-209
Hauptverfasser:	Kmetič, I, Gaurina Srček, V, Slivac, I, Šimić, B, Kniewald, Z, Kniewald, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Aquatic Pollution Atrazine Atrazine - toxicity Bioassays Cell Proliferation - drug effects CHO Cells Coloring Agents Cricetinae Cricetulus Cytotoxicity Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Health risk assessment Herbicides Herbicides - toxicity Microscopy, Fluorescence Necrosis - chemically induced Necrosis - pathology Neutral Red Organic Chemicals Pollution Reproductive system Rodents Soil Science & Conservation Studies Tetrazolium Salts Thiazoles Toxicity Trypan Blue Waste Water Technology Water Management Water Pollution Control
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Zusammenfassung:	The aim of this study was to determine the toxic effect of atrazine at the ovarian cellular level. Chinese Hamster Ovary (CHO-K1) cell line was used to evaluate the degree of in vitro atrazine cytotoxicity and the morphological changes were followed during the cell death. Application of four bioassays confirmed that atrazine decreases ovarian cell proliferation and IC₅₀ were determined with each assay after 72 h of exposure. The level of apoptosis in atrazine treated cells was low.
ISSN:	0007-4861 1432-0800
DOI:	10.1007/s00128-008-9425-6