Isolation and structure determination of cassumunarins A, B, and C: new anti-inflammatory antioxidants from a tropical ginger, Zingiber cassumunar

New antioxidants, cassumunarins A, B, and C, were isolated from the rhizomes ofZingiber cassumunar, and the structures were determined by spectroscopic methods to be complex curcuminoids. The antixidant efficiency of cassumunarins was determined by inhibitory activity of autoxidation of linoleic aci...

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Veröffentlicht in:	Journal of the American Oil Chemists' Society 1995-09, Vol.72 (9), p.1053-1057
Hauptverfasser:	Masuda, T. (Osaka City University, Sumiyoshi, Osaka, Japan.), Jitoe, A, Mabry, T.J
Format:	Artikel
Sprache:	eng
Schlagworte:	ANTIINFLAMMATOIRE ANTIINFLAMMATORY AGENTS ANTINFLAMATORIOS antioxidant ANTIOXIDANTES ANTIOXIDANTS ANTIOXYDANT Anti‐inflammation Biological and medical sciences curcuminoid ESPECTROMETRIA EXTRACTOS VEGETALES EXTRAIT D'ORIGINE VEGETALE General pharmacology isolation Medical sciences Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments PLANT EXTRACTS PURIFICACION PURIFICATION RHIZOME RHIZOMES RIZOMAS SPECTRAL DATA SPECTROMETRIE SPECTROMETRY structure determination ZINGIBER Zingiber cassumunar
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Zusammenfassung:	New antioxidants, cassumunarins A, B, and C, were isolated from the rhizomes ofZingiber cassumunar, and the structures were determined by spectroscopic methods to be complex curcuminoids. The antixidant efficiency of cassumunarins was determined by inhibitory activity of autoxidation of linoleic acid in a buffer‐ethanol system. The anti‐inflammatory effect was measured by inhibition of edema formation on mouse ear induced by 12‐O‐tetradecanoylphorbol‐13‐acetate. Both types of activities were stronger for the cassumunarins than for the curcumin.
ISSN:	0003-021X 1558-9331
DOI:	10.1007/bf02660721