Association of immune system gene polymorphisms with quantitative traits pathogenetically important for chronic virus hepatitis

Association of immune system gene polymorphisms with quantitative traits pathogenetically important for chronic virus hepatitis

The IL4 C(−590)T, IL4RA Ile50Val, and TNF G(−308)A polymorphisms were tested for association with quantitative traits important for chronic virus hepatitis, including the levels of IL4, IL10, IL12, TNF-α, fibronectin, collagenase, the proteinase inhibitor, macroglobulin, and free and protein-bound (...

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Veröffentlicht in:Molecular biology (New York) 2008-04, Vol.42 (2), p.213-216
Hauptverfasser: Goncharova, I. A., Beloborodova, E. V., Freidin, M. B., Beloborodova, E. I., Chernogoruk, G. E., Puzyrev, V. P.
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Collagenase
Cytokines
Fibronectin
Gene polymorphism
Genomics
Genomics. Transcriptomics. Proteomics
Hepatitis
Human Genetics
Immune system
Interleukin 10
Interleukin 12
Interleukin 4
Leukocytes (mononuclear)
Life Sciences
Macroglobulins
Molecular biology
Polymorphism
Proteinase inhibitors
Proteomics
Quantitative genetics
Tumor necrosis factor-a
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Zusammenfassung:The IL4 C(−590)T, IL4RA Ile50Val, and TNF G(−308)A polymorphisms were tested for association with quantitative traits important for chronic virus hepatitis, including the levels of IL4, IL10, IL12, TNF-α, fibronectin, collagenase, the proteinase inhibitor, macroglobulin, and free and protein-bound (PBO) oxyproline. Allele A of the TNF G(−308)A polymorphism was associated with a lower TNF-α production by mononuclear cells, a higher production of IL4 and IL12, and a lower PBO level. The genotype CT of the IL4 C(−590)T polymorphism was associated with a high PBO level.
ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893308020064