Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

We describe the fast reaction kinetics between 1,2-aminothiols and aldehydes. Under physiological conditions such a click-type reaction afforded a thiazolidine product that remains stable and did not require any catalyst. This type of bioorthogonal reaction offers enormous potential for the coupling...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018, Vol.54 (88), p.1257-1251
Hauptverfasser:	Bermejo-Velasco, Daniel, Nawale, Ganesh N, Oommen, Oommen P, Hilborn, Jöns, Varghese, Oommen P
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Biocompatibility Biomolecules Organic chemistry Physiology Reaction kinetics
Online-Zugang:	Volltext
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