Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

We describe the fast reaction kinetics between 1,2-aminothiols and aldehydes. Under physiological conditions such a click-type reaction afforded a thiazolidine product that remains stable and did not require any catalyst. This type of bioorthogonal reaction offers enormous potential for the coupling of biomolecules in an efficient and biocompatible manner. We describe the fast reaction kinetics between 1,2-aminothiols and aldehydes that afforded a stable thiazolidine product under physiological pH. This efficient and biocompatible reaction offers enormous potential for the coupling of biomolecules.