Interleukin-18 increases metastasis and immune escape of stomach cancer via the downregulation of CD70 and maintenance of CD44

Cancer cells metastasize to the other site after escaping from the immune system and CD70, CD44 and vascular endothelial growth factor (VEGF) play important roles in this process. It is recently reported that interleukin (IL)-18 is closely related with the pathogenesis of skin tumor. Therefore, we i...

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Veröffentlicht in:	Carcinogenesis (New York) 2009-12, Vol.30 (12), p.1987-1996
Hauptverfasser:	Kang, Jae Seung, Y.Bae, Seyeon, R.Kim, Hangrae, Kim, Yeong Seok, J.Kim, Daejin, Cho, Byung Joo, Yang, Han-Kwang, Hwang, Young-Il, J.Kim, Kyungjae, Park, Hong Suk, H.Hwang, Doukho, J.Cho, Daeho, Lee, Wang Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens CD27 Ligand - biosynthesis Cell Line, Tumor Down-Regulation Female Gastroenterology. Liver. Pancreas. Abdomen Gene Expression Regulation, Neoplastic Humans Hyaluronan Receptors - biosynthesis Immune System Interleukin-18 - metabolism Interleukin-18 - physiology Medical sciences Mice Mice, Inbred BALB C Mice, Nude Neoplasm Metastasis RNA, Small Interfering - metabolism Stomach Neoplasms - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors Vascular Endothelial Growth Factor A - metabolism
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Zusammenfassung:	Cancer cells metastasize to the other site after escaping from the immune system and CD70, CD44 and vascular endothelial growth factor (VEGF) play important roles in this process. It is recently reported that interleukin (IL)-18 is closely related with the pathogenesis of skin tumor. Therefore, we investigated the role of endogenous IL-18 from stomach cancer on the immune escape mechanism and metastasis via the regulation of CD70, CD44 and VEGF expression. IL-18 and IL-18R expressions were not only investigated on tumor tissues (n = 10), and sera (n = 20) from stomach cancer patients, but also on human stomach cancer cell lines. IL-18 and IL-18R expressions were found on stomach cancer cell lines and tumor tissues. In addition, IL-18 levels were elevated in sera from cancer patients (P
ISSN:	0143-3334 1460-2180
DOI:	10.1093/carcin/bgp158