Same‐session endoscopic ultrasound‐guided fine needle aspiration and endoscopic retrograde cholangiopancreatography‐based tissue sampling in suspected malignant biliary obstruction: A multicenter experience

Background and Aim Few studies compared endoscopic ultrasound (EUS)‐guided fine needle aspiration (EUS‐FNA) with endoscopic retrograde cholangiopancreatography (ERCP)‐based tissue sampling in terms of diagnostic accuracy in suspected malignant biliary obstruction. We evaluated and compared the diagnostic performance of EUS‐FNA and ERCP‐based tissue sampling. Methods This multicenter study included 263 patients with suspected malignant biliary obstruction who underwent same‐session EUS and ERCP between 2012 and 2016. Results Malignancies were confirmed in 239 patients (90.9%) and benign in 24 patients (9.1%). Overall diagnostic sensitivity and accuracy were 73.6% and 76.1% for EUS‐FNA, 56.5% and 60.5% for ERCP, and 85.8% and 87.1% for EUS/ERCP combination. EUS‐FNA showed higher overall performances compared with ERCP (P