Activation of [alpha]-Latrotoxin Receptors in Neuromuscular Synapses Leads to a Prolonged Splash Acetylcholine Release

Activation of [alpha]-Latrotoxin Receptors in Neuromuscular Synapses Leads to a Prolonged Splash Acetylcholine Release

The mechanisms of acetylcholine release in presynaptic terminals of motoneurons induced by mutant α-latrotoxin (LTN4C) were analyzed. In contrast to wild-type α-latrotoxin that causes both continuous and splash secretion of acetylcholine and necessarity block neuromuscular transmission, LTN4C causes...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2009-06, Vol.147 (6), p.701-703
Hauptverfasser: Lelyanova, V G, Thomson, D, Ribchester, R R, Tonevitsky, E A, Ushkaryov, Y A
Format: Artikel
Sprache:eng
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Zusammenfassung:The mechanisms of acetylcholine release in presynaptic terminals of motoneurons induced by mutant α-latrotoxin (LTN4C) were analyzed. In contrast to wild-type α-latrotoxin that causes both continuous and splash secretion of acetylcholine and necessarity block neuromuscular transmission, LTN4C causes only splash release lasting over many hours. Thus, activation of α-latrotoxin receptors controls long-lasting enhanced secretion of acetylcholine.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-009-0600-5