miR‐145‐5p affects the differentiation of gastric cancer by targeting KLF5 directly

Krüppel‐like factor 5 (KLF5) takes part in the pathologic processes of many types of cancer; however, its expression and roles in the biological behavior of gastric cancer remain unknown. TargetScan suggested that miR‐145‐5p is the predicted effective and conserved microRNA (miRNA) that binds to KLF...

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Veröffentlicht in:	Journal of cellular physiology 2019-05, Vol.234 (5), p.7634-7644
Hauptverfasser:	Zhou, Taicheng, Chen, Shuang, Mao, Xiaoyun
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated regions 3' Untranslated Regions - genetics Adult Aged Aged, 80 and over Cancer Cell Differentiation - genetics Cell Line, Tumor Differentiation Down-Regulation - genetics Female Gastric cancer Gene expression Gene Expression Regulation, Neoplastic - genetics Humans Immunohistochemistry KLF5 Kruppel-Like Transcription Factors - genetics Male MicroRNAs - genetics Middle Aged miRNA miR‐145‐5p mRNA Mucosa Ribonucleic acid RNA RNA, Messenger - genetics Stomach Neoplasms - genetics Transfection Transfection - methods undifferentiated subtype
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Zusammenfassung:	Krüppel‐like factor 5 (KLF5) takes part in the pathologic processes of many types of cancer; however, its expression and roles in the biological behavior of gastric cancer remain unknown. TargetScan suggested that miR‐145‐5p is the predicted effective and conserved microRNA (miRNA) that binds to KLF5 through its 3′‐untranslated region (UTR). We investigated the expression of KLF5 and miR‐145‐5p messenger RNA (mRNA) in gastric cancer and then analyzed its role in the biological behavior of gastric cancer cells. Our results indicated that KLF5 expression was detected by immunohistochemistry in 39.7% of the gastric cancer cases and was increased compared with that of the corresponding noncancerous normal mucosa (0.01
ISSN:	0021-9541 1097-4652
DOI:	10.1002/jcp.27525