Implementation and evaluation of high-dose methotrexate administration guidelines

Background High-dose methotrexate is used to treat a variety of malignancies. Methotrexate-associated supportive care and the threshold methotrexate level for the discontinuation of supportive care are not consistent among studies. We evaluated the implementation of high-dose methotrexate administra...

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Veröffentlicht in:	Journal of oncology pharmacy practice 2019-10, Vol.25 (7), p.1675-1681
Hauptverfasser:	Nowak, Thomas J, Lorge, Aaron H, Rein, Lisa E, Canadeo, Angela M, Frank, Joel P, Samanas, Lisa C, Urmanski, Angela M, Atallah, Ehab L
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic - administration & dosage Female Guidelines Humans Infusions, Intravenous Male Methotrexate Methotrexate - administration & dosage Middle Aged Neoplasms - diagnosis Neoplasms - drug therapy Palliative Care - methods Palliative Care - standards Patient Discharge - standards Practice Guidelines as Topic - standards Prospective Studies Retrospective Studies Sodium Sodium bicarbonate Sodium Bicarbonate - administration & dosage Young Adult
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Zusammenfassung:	Background High-dose methotrexate is used to treat a variety of malignancies. Methotrexate-associated supportive care and the threshold methotrexate level for the discontinuation of supportive care are not consistent among studies. We evaluated the implementation of high-dose methotrexate administration guidelines, which raised the standard threshold methotrexate level for the discontinuation of supportive care from
ISSN:	1078-1552 1477-092X
DOI:	10.1177/1078155218808866