SLAMF6 in health and disease: Implications for therapeutic targeting

•SLAMF6 is a cell surface receptor, expressed only on hematopoietic cells•SLAMF6 receptor can positively or negatively regulate immune responses•SLAMF6 is implicated in autoimmunity and cancer and this receptor can be targeted to help improve current treatment in various diseases.

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Veröffentlicht in:Clinical immunology (Orlando, Fla.) Fla.), 2019-07, Vol.204, p.3-13
Hauptverfasser: Yigit, Burcu, Wang, Ninghai, Herzog, Roland W., Terhorst, Cox
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container_title Clinical immunology (Orlando, Fla.)
container_volume 204
creator Yigit, Burcu
Wang, Ninghai
Herzog, Roland W.
Terhorst, Cox
description •SLAMF6 is a cell surface receptor, expressed only on hematopoietic cells•SLAMF6 receptor can positively or negatively regulate immune responses•SLAMF6 is implicated in autoimmunity and cancer and this receptor can be targeted to help improve current treatment in various diseases.
doi_str_mv 10.1016/j.clim.2018.10.013
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subjects Animals
Humans
Neoplasms - immunology
Signaling Lymphocytic Activation Molecule Family - immunology
title SLAMF6 in health and disease: Implications for therapeutic targeting
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