HPLC study of the pharmacokinetics of K-203

HPLC study of the pharmacokinetics of K-203

The pharmacokinetics of K-203, a recently synthesized bis-pyridinium aidoxime, have been investigated by reversed-phase HPLC. The K-203 content of serum samples was monitored by HPLC with ultraviolet absorbance detection at 286 nm. The low concentration of K-203 in samples of brain, eyes, and cerebr...

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Veröffentlicht in:Acta chromatographica 2008-12, Vol.20 (4), p.575-584
Hauptverfasser: Kalász, H., Laufer, R., Szegi, P., Kuca, K., Musilek, K., Tekes, K.
Format: Artikel
Sprache:eng
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Zusammenfassung:The pharmacokinetics of K-203, a recently synthesized bis-pyridinium aidoxime, have been investigated by reversed-phase HPLC. The K-203 content of serum samples was monitored by HPLC with ultraviolet absorbance detection at 286 nm. The low concentration of K-203 in samples of brain, eyes, and cerebrospinal fluid was also determined by HPLC; quantitative evaluation was possible by use of an amperometric detector.
ISSN:1233-2356
2083-5736
DOI:10.1556/AChrom.20.2008.4.4