Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU

In a randomized trial comparing the proton-pump inhibitor pantoprazole with placebo in the ICU, there was no significant difference in the rate of death at 90 days or in a combined end point of clinically meaningful events, which included gastrointestinal bleeding and pneumonia.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2018-12, Vol.379 (23), p.2199-2208
Hauptverfasser:	Krag, Mette, Marker, Søren, Perner, Anders, Wetterslev, Jørn, Wise, Matt P, Schefold, Joerg C, Keus, Frederik, Guttormsen, Anne B, Bendel, Stepani, Borthwick, Mark, Lange, Theis, Rasmussen, Bodil S, Siegemund, Martin, Bundgaard, Helle, Elkmann, Thomas, Jensen, Jacob V, Nielsen, Rune D, Liboriussen, Lisbeth, Bestle, Morten H, Elkjær, Jeanie M, Palmqvist, Dorte F, Bäcklund, Minna, Laake, Jon H, Bådstøløkken, Per M, Grönlund, Juha, Breum, Olena, Walli, Akil, Winding, Robert, Iversen, Susanne, Jarnvig, Inge-Lise, White, Jonathan O, Brand, Björn, Madsen, Martin B, Quist, Lars, Thornberg, Klaus J, Møller, Anders, Wiis, Jørgen, Granholm, Anders, Anthon, Carl T, Meyhoff, Tine S, Hjortrup, Peter B, Aagaard, Søren R, Andreasen, Jo B, Sørensen, Christina A, Haure, Pernille, Hauge, Jacob, Hollinger, Alexa, Scheuzger, Jonas, Tuchscherer, Daniel, Vuilliomenet, Thierry, Takala, Jukka, Jakob, Stephan M, Vang, Marianne L, Pælestik, Kim B, Andersen, Karen L.D, van der Horst, Iwan C.C, Dieperink, Willem, Fjølner, Jesper, Kjer, Cilia K.W, Sølling, Christine, Sølling, Christoffer G, Karttunen, Johanna, Morgan, Matt P.G, Sjøbø, Brit, Engstrøm, Janus, Agerholm-Larsen, Birgit, Møller, Morten H
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Bleeding Blood pressure Consent Critical care Critical Illness - mortality Critical Illness - therapy Female Gastrointestinal Hemorrhage - epidemiology Gastrointestinal Hemorrhage - prevention & control Humans Injections, Intravenous Intensive care Intensive Care Units Intravenous administration Ischemia Male Middle Aged Mortality Myocardial ischemia Nosocomial infections Nutrition Pantoprazole - adverse effects Pantoprazole - therapeutic use Patients Peptic Ulcer - prevention & control Pneumonia Prophylaxis Proton pump inhibitors Proton Pump Inhibitors - adverse effects Proton Pump Inhibitors - therapeutic use Risk Factors Single-Blind Method Stress, Physiological Survival Analysis Ulcers Ventilators
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Beschreibung
Zusammenfassung:	In a randomized trial comparing the proton-pump inhibitor pantoprazole with placebo in the ICU, there was no significant difference in the rate of death at 90 days or in a combined end point of clinically meaningful events, which included gastrointestinal bleeding and pneumonia.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa1714919