Misclassification of Calcium Status Based on Albumin-Adjusted Calcium: Studies in a Tertiary Hospital Setting

Clinical laboratories measure total calcium and adjust for albumin concentrations to predict calcium status. We compared total and adjusted calcium (Adj-Ca) with ionized calcium (Ca ) for correct assignment of calcium status. The effect of restriction of Adj-Ca reporting in patients with hypoalbumin...

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Veröffentlicht in:	Clinical chemistry (Baltimore, Md.) Md.), 2018-12, Vol.64 (12), p.1713-1722
Hauptverfasser:	Smith, Joel D, Wilson, Scott, Schneider, Hans G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Albumin Blood Chemical Analysis - methods Calcium Calcium - blood Calcium ions Classification Creatinine - blood Data Interpretation, Statistical Datasets Female Hemodialysis Hospitals Humans Hypercalcemia - blood Hypocalcemia - blood Kidney diseases Laboratories Laboratories, Hospital Male Middle Aged Patients Predictive Value of Tests Prospective Studies Renal failure Renal function Retrospective Studies Serum Albumin, Human - analysis Statistical analysis Statistical methods Tertiary Care Centers Young Adult
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Zusammenfassung:	Clinical laboratories measure total calcium and adjust for albumin concentrations to predict calcium status. We compared total and adjusted calcium (Adj-Ca) with ionized calcium (Ca ) for correct assignment of calcium status. The effect of restriction of Adj-Ca reporting in patients with hypoalbuminemia was determined on the basis of frequency of misclassifications. Extraction of laboratory results was performed for 24 months. Adj-Ca was calculated from a modified Payne formula. A further prospective data set for 6 months was collected after stopping reporting of Adj-Ca for patients with an albumin
ISSN:	0009-9147 1530-8561
DOI:	10.1373/clinchem.2018.291377