Lighting up alkaline phosphatase in drug-induced liver injury using a new chemiluminescence resonance energy transfer nanoprobe

Lighting up alkaline phosphatase in drug-induced liver injury using a new chemiluminescence resonance energy transfer nanoprobe

We present a new nanoprobe based on chemiluminescence resonance energy transfer for in vivo imaging of drug-induced alkaline phosphatase (ALP). This probe exhibits the perfect degrees of high sensitivity and specificity for real-time monitoring of ALP levels to directly evaluate drug-induced liver i...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2018, Vol.54 (88), p.12479-12482
Hauptverfasser: Liu, Xueting, Fan, Nannan, Wu, Lijie, Wu, Chuanchen, Zhou, Yongqing, Li, Ping, Tang, Bo
Format: Artikel
Sprache:eng
Schlagworte:
Alkaline phosphatase
Chemiluminescence
Energy transfer
Liver
Organic chemistry
Phosphatase
Sensitivity analysis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We present a new nanoprobe based on chemiluminescence resonance energy transfer for in vivo imaging of drug-induced alkaline phosphatase (ALP). This probe exhibits the perfect degrees of high sensitivity and specificity for real-time monitoring of ALP levels to directly evaluate drug-induced liver injury.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc07211f