Effect of early‐life inflammation and magnesium sulfate on hyperthermia‐induced seizures in infant rats: Susceptibility to pentylenetetrazol‐induced seizures later in life

This study investigated the effect of inflammation and MgSO4 pretreatment on behaviors caused by hyperthermia (HT) and the effect of these interventions on PTZ‐induced seizure a week later. In this experimental study, rat pups experienced inflammation on postnatal day 10 (P10). On P18–19, the pups received either saline or MgSO4 then subjected to hyperthermia. On P25–26, PTZ‐induced seizure was initiated in the rats. Neonatal inflammation increased the susceptibility to HT‐induced seizure. Inflammation and HT increased the susceptibility to PTZ‐induced seizure. Pretreatment with MgSO4 before hyperthermia decreased the susceptibility to both HT‐ and PTZ‐induced seizure. Furthermore, calcium and magnesium blood levels significantly decreased compared to control rats. It can be concluded that neonatal inflammation potentiates while pretreatment with MgSO4 attenuates HT‐induced seizures. Also, neonatal inflammation and HT potentiate PTZ‐induced seizure initiated one week later.