Glutathione system and activity of NADPH-generating enzymes in the liver of intact rats and animals with toxic hepatitis receiving melatonin

Melatonin administered to intact animals increased glutathione concentration and activities of glutathione peroxidase, glutathione reductase, NADP-isocitrate dehydrogenase, and glucose-6-phosphate dehydrogenase in the liver. In animals with toxic hepatitis melatonin treatment decreased glutathione c...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2005-05, Vol.139 (5), p.565-568
Hauptverfasser:	Pashkov, A N, Popov, S S, Semenikhina, A V, Rakhmanova, T I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - physiopathology Glucosephosphate Dehydrogenase - metabolism Glutathione - metabolism Glutathione Peroxidase - metabolism Glutathione Reductase - metabolism Isocitrate Dehydrogenase - metabolism Liver - drug effects Liver - enzymology Male Melatonin - pharmacology NADP - metabolism Oxidation-Reduction Rats
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Beschreibung
Zusammenfassung:	Melatonin administered to intact animals increased glutathione concentration and activities of glutathione peroxidase, glutathione reductase, NADP-isocitrate dehydrogenase, and glucose-6-phosphate dehydrogenase in the liver. In animals with toxic hepatitis melatonin treatment decreased glutathione concentration and enzyme activities, which was probably associated with inhibition of free radical oxidation under the influence of this hormone.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-005-0346-7