Cytokine profiles in patients receiving wide-field + prostate boost radiotherapy (xRT) for adenocarcinoma of the prostate
As a result of the association between ionizing irradiation and the induction of inflammatory and fibrogenic cytokines, circulating levels of IL-1α, macrophage colony stimulating factor (M-CSF) and TGFβ were measured in a group of 37 patients who presented with well-defined adenocarcinoma of the pro...
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| Veröffentlicht in: | Cytokine (Philadelphia, Pa.) Pa.), 2003-09, Vol.23 (6), p.151-163 |
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| creator | Kovacs, C.J. Daly, B.M. Evans, M.J. Johnke, R.M. Lee, T.K. Karlsson, U.L. Allison, R. Eaves, G.S. Biggs, L.M. |
| description | As a result of the association between ionizing irradiation and the induction of inflammatory and fibrogenic cytokines, circulating levels of IL-1α, macrophage colony stimulating factor (M-CSF) and TGFβ were measured in a group of 37 patients who presented with well-defined adenocarcinoma of the prostate and were treated with wide-field pelvic (WFP) + prostate boost (PB) radiotherapy (xRT) according to RTOG protocols 94-08 and 94-13. First and foremost, patients with prostate cancer (PC) were found to have a significantly (
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| doi_str_mv | 10.1016/S1043-4666(03)00185-6 |
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p<0.05) elevated plasma level of the three cytokines prior to treatment. Moreover, during WFP + PB xRT, these circulating cytokine levels were further elevated, the elevation occurring in the form of cyclic waves; the concurrent waves of elevated IL-1α and M-CSF preceding that of TGFβ. In addition to providing support for the existence of a humoral response to xRT in patients receiving WFP + PB xRT, the data demonstrated a significant correlation between the integral radiation dose (ID) and the temporal expression and magnitude of plasma IL-1α, M-CSF and TGFβ levels in patients that had received 1–5 fractions (1.8–9
Gy) of WFP + PB xRT. Thereafter, the appearance of elevated waves of cytokine expression in the patient's plasma continued independent of additional fractions of WFP + PB xRT.</description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/S1043-4666(03)00185-6</identifier><identifier>PMID: 12967640</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adenocarcinoma - blood ; Adenocarcinoma - radiotherapy ; African Americans ; Aged ; Aged, 80 and over ; Cytokine profiles ; Cytokines - blood ; Dose-Response Relationship, Radiation ; European Continental Ancestry Group ; Humans ; Interleukin-1 - blood ; Macrophage Colony-Stimulating Factor - blood ; Male ; Middle Aged ; Prostate cancer ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - radiotherapy ; Radiotherapy ; Radiotherapy Dosage ; Transforming Growth Factor beta - blood</subject><ispartof>Cytokine (Philadelphia, Pa.), 2003-09, Vol.23 (6), p.151-163</ispartof><rights>2003 Elsevier Science Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-a246f2601279d8d027686c98a7f33277911ed1a161cdc31b61aec0c9e0c279403</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S1043-4666(03)00185-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12967640$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kovacs, C.J.</creatorcontrib><creatorcontrib>Daly, B.M.</creatorcontrib><creatorcontrib>Evans, M.J.</creatorcontrib><creatorcontrib>Johnke, R.M.</creatorcontrib><creatorcontrib>Lee, T.K.</creatorcontrib><creatorcontrib>Karlsson, U.L.</creatorcontrib><creatorcontrib>Allison, R.</creatorcontrib><creatorcontrib>Eaves, G.S.</creatorcontrib><creatorcontrib>Biggs, L.M.</creatorcontrib><title>Cytokine profiles in patients receiving wide-field + prostate boost radiotherapy (xRT) for adenocarcinoma of the prostate</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description>As a result of the association between ionizing irradiation and the induction of inflammatory and fibrogenic cytokines, circulating levels of IL-1α, macrophage colony stimulating factor (M-CSF) and TGFβ were measured in a group of 37 patients who presented with well-defined adenocarcinoma of the prostate and were treated with wide-field pelvic (WFP) + prostate boost (PB) radiotherapy (xRT) according to RTOG protocols 94-08 and 94-13. First and foremost, patients with prostate cancer (PC) were found to have a significantly (
p<0.05) elevated plasma level of the three cytokines prior to treatment. Moreover, during WFP + PB xRT, these circulating cytokine levels were further elevated, the elevation occurring in the form of cyclic waves; the concurrent waves of elevated IL-1α and M-CSF preceding that of TGFβ. In addition to providing support for the existence of a humoral response to xRT in patients receiving WFP + PB xRT, the data demonstrated a significant correlation between the integral radiation dose (ID) and the temporal expression and magnitude of plasma IL-1α, M-CSF and TGFβ levels in patients that had received 1–5 fractions (1.8–9
Gy) of WFP + PB xRT. Thereafter, the appearance of elevated waves of cytokine expression in the patient's plasma continued independent of additional fractions of WFP + PB xRT.</description><subject>Adenocarcinoma - blood</subject><subject>Adenocarcinoma - radiotherapy</subject><subject>African Americans</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cytokine profiles</subject><subject>Cytokines - blood</subject><subject>Dose-Response Relationship, Radiation</subject><subject>European Continental Ancestry Group</subject><subject>Humans</subject><subject>Interleukin-1 - blood</subject><subject>Macrophage Colony-Stimulating Factor - blood</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>Radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>Transforming Growth Factor beta - blood</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFu1DAQhi0EakvpI4B8Qq2q0Bk7tZNThVZQKlVCouVsee0JGLLxYnsL-_Y43RU9cpo5fL__8cfYa4R3CKgu7hBa2bRKqVOQZwDYXTbqGTtC6FUDIOTzed8jh-xlzj8AoJdaH7BDFL3SqoUjtl1sS_wZJuLrFIcwUuZh4mtbAk0l80SOwkOYvvHfwVMzBBo9P5_ZXGwhvox14cn6EMt3Sna95ad_vtyf8SEmbj1N0dnkwhRXlseBV-Zf9hV7Mdgx08l-HrOvHz_cLz41t5-vbxbvbxsntSyNFa0ahAIUuvedB6FVp1zfWT1IKbTuEcmjRYXOO4lLhZYcuJ7A1UQL8pi93b1bi39tKBezCtnRONqJ4iYbgUIK7FQFL3egqxfmRINZp7CyaWsQzOzcPDo3s1AD0jw6N3Puzb5gs1yRf0rtJVfgagdQ_eZDoGSyq3od-VD9FuNj-E_FXxwNkcw</recordid><startdate>20030921</startdate><enddate>20030921</enddate><creator>Kovacs, C.J.</creator><creator>Daly, B.M.</creator><creator>Evans, M.J.</creator><creator>Johnke, R.M.</creator><creator>Lee, T.K.</creator><creator>Karlsson, U.L.</creator><creator>Allison, R.</creator><creator>Eaves, G.S.</creator><creator>Biggs, L.M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20030921</creationdate><title>Cytokine profiles in patients receiving wide-field + prostate boost radiotherapy (xRT) for adenocarcinoma of the prostate</title><author>Kovacs, C.J. ; Daly, B.M. ; Evans, M.J. ; Johnke, R.M. ; Lee, T.K. ; Karlsson, U.L. ; Allison, R. ; Eaves, G.S. ; Biggs, L.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-a246f2601279d8d027686c98a7f33277911ed1a161cdc31b61aec0c9e0c279403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adenocarcinoma - blood</topic><topic>Adenocarcinoma - radiotherapy</topic><topic>African Americans</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cytokine profiles</topic><topic>Cytokines - blood</topic><topic>Dose-Response Relationship, Radiation</topic><topic>European Continental Ancestry Group</topic><topic>Humans</topic><topic>Interleukin-1 - blood</topic><topic>Macrophage Colony-Stimulating Factor - blood</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>Radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>Transforming Growth Factor beta - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kovacs, C.J.</creatorcontrib><creatorcontrib>Daly, B.M.</creatorcontrib><creatorcontrib>Evans, M.J.</creatorcontrib><creatorcontrib>Johnke, R.M.</creatorcontrib><creatorcontrib>Lee, T.K.</creatorcontrib><creatorcontrib>Karlsson, U.L.</creatorcontrib><creatorcontrib>Allison, R.</creatorcontrib><creatorcontrib>Eaves, G.S.</creatorcontrib><creatorcontrib>Biggs, L.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kovacs, C.J.</au><au>Daly, B.M.</au><au>Evans, M.J.</au><au>Johnke, R.M.</au><au>Lee, T.K.</au><au>Karlsson, U.L.</au><au>Allison, R.</au><au>Eaves, G.S.</au><au>Biggs, L.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytokine profiles in patients receiving wide-field + prostate boost radiotherapy (xRT) for adenocarcinoma of the prostate</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2003-09-21</date><risdate>2003</risdate><volume>23</volume><issue>6</issue><spage>151</spage><epage>163</epage><pages>151-163</pages><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract>As a result of the association between ionizing irradiation and the induction of inflammatory and fibrogenic cytokines, circulating levels of IL-1α, macrophage colony stimulating factor (M-CSF) and TGFβ were measured in a group of 37 patients who presented with well-defined adenocarcinoma of the prostate and were treated with wide-field pelvic (WFP) + prostate boost (PB) radiotherapy (xRT) according to RTOG protocols 94-08 and 94-13. First and foremost, patients with prostate cancer (PC) were found to have a significantly (
p<0.05) elevated plasma level of the three cytokines prior to treatment. Moreover, during WFP + PB xRT, these circulating cytokine levels were further elevated, the elevation occurring in the form of cyclic waves; the concurrent waves of elevated IL-1α and M-CSF preceding that of TGFβ. In addition to providing support for the existence of a humoral response to xRT in patients receiving WFP + PB xRT, the data demonstrated a significant correlation between the integral radiation dose (ID) and the temporal expression and magnitude of plasma IL-1α, M-CSF and TGFβ levels in patients that had received 1–5 fractions (1.8–9
Gy) of WFP + PB xRT. Thereafter, the appearance of elevated waves of cytokine expression in the patient's plasma continued independent of additional fractions of WFP + PB xRT.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>12967640</pmid><doi>10.1016/S1043-4666(03)00185-6</doi><tpages>13</tpages></addata></record> |
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| subjects | Adenocarcinoma - blood Adenocarcinoma - radiotherapy African Americans Aged Aged, 80 and over Cytokine profiles Cytokines - blood Dose-Response Relationship, Radiation European Continental Ancestry Group Humans Interleukin-1 - blood Macrophage Colony-Stimulating Factor - blood Male Middle Aged Prostate cancer Prostatic Neoplasms - blood Prostatic Neoplasms - radiotherapy Radiotherapy Radiotherapy Dosage Transforming Growth Factor beta - blood |
| title | Cytokine profiles in patients receiving wide-field + prostate boost radiotherapy (xRT) for adenocarcinoma of the prostate |
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