Cytokine profiles in patients receiving wide-field + prostate boost radiotherapy (xRT) for adenocarcinoma of the prostate

As a result of the association between ionizing irradiation and the induction of inflammatory and fibrogenic cytokines, circulating levels of IL-1α, macrophage colony stimulating factor (M-CSF) and TGFβ were measured in a group of 37 patients who presented with well-defined adenocarcinoma of the pro...

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Veröffentlicht in:	Cytokine (Philadelphia, Pa.) Pa.), 2003-09, Vol.23 (6), p.151-163
Hauptverfasser:	Kovacs, C.J., Daly, B.M., Evans, M.J., Johnke, R.M., Lee, T.K., Karlsson, U.L., Allison, R., Eaves, G.S., Biggs, L.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood Adenocarcinoma - radiotherapy African Americans Aged Aged, 80 and over Cytokine profiles Cytokines - blood Dose-Response Relationship, Radiation European Continental Ancestry Group Humans Interleukin-1 - blood Macrophage Colony-Stimulating Factor - blood Male Middle Aged Prostate cancer Prostatic Neoplasms - blood Prostatic Neoplasms - radiotherapy Radiotherapy Radiotherapy Dosage Transforming Growth Factor beta - blood
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Zusammenfassung:	As a result of the association between ionizing irradiation and the induction of inflammatory and fibrogenic cytokines, circulating levels of IL-1α, macrophage colony stimulating factor (M-CSF) and TGFβ were measured in a group of 37 patients who presented with well-defined adenocarcinoma of the prostate and were treated with wide-field pelvic (WFP) + prostate boost (PB) radiotherapy (xRT) according to RTOG protocols 94-08 and 94-13. First and foremost, patients with prostate cancer (PC) were found to have a significantly ( p
ISSN:	1043-4666 1096-0023
DOI:	10.1016/S1043-4666(03)00185-6