Neuropeptide carnosine increases stability of lipoproteins and red blood cells as well as efficiency of immune competent system in patients with chronic discirculatory encephalopathy

Carnosine administration (in a daily dose of 2 g) as an additional therapy for patients with chronic discirculatory encephalopathy (DE) results in an increase in stability of blood plasma lipoproteins toward Fe 2+ -induced oxidation and stabilization of red blood cells against acidic hemolysis as well as intensification of respiratory burst of periphery blood leucocytes. At the same time, latent period of brain induced potentials, P300, decreases and the proportion of the high-amplitude induced potentials increases. The data presented demonstrate that carnosine enhances the efficiency of basal therapy of DE patients.