Variation in the safety of induced pluripotent stem cell lines

We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells...

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Veröffentlicht in:	Nature biotechnology 2009-08, Vol.27 (8), p.743-745
Hauptverfasser:	Okada, Aki, Nakagawa, Masato, Takahashi, Kazutoshi, Okita, Keisuke, Tanabe, Koji, Okada, Yohei, Okano, Hideyuki, Miura, Kyoko, Ogawa, Daisuke, Ikeda, Eiji, Yamanaka, Shinya, Ohnuki, Mari, Aoi, Takashi, Koyanagi, Michiyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Animals Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedical research Biomedicine Biotechnology brief-communication Cell Line Cell Transformation, Neoplastic - pathology Embryos Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Life Sciences Mice Miscellaneous Neurons Neurons - cytology Pluripotent Stem Cells - cytology Safety Stem cell research Stem cells Teratoma Teratoma - pathology
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Zusammenfassung:	We evaluated the teratoma-forming propensity of secondary neurospheres (SNS) generated from 36 mouse induced pluripotent stem (iPS) cell lines derived in 11 different ways. Teratoma-formation of SNS from embryonic fibroblast-derived iPS cells was similar to that of SNS from embryonic stem (ES) cells. In contrast, SNS from iPS cells derived from different adult tissues varied substantially in their teratoma-forming propensity, which correlated with the persistence of undifferentiated cells.
ISSN:	1087-0156 1546-1696
DOI:	10.1038/nbt.1554