Physiological Role of IL-15 and IL-18 at the Maternal-Fetal Interface

Physiological Role of IL-15 and IL-18 at the Maternal-Fetal Interface

We review recent studies of two cytokines IL-15 and IL-18, showing that they are the critical cytokines controlling uterine NK cell cytokine production and cytolytic potential. Further, IL-15 has been implicated in differentiation and proliferation of uterine NK cells, while IL-18 enhanced innate im...

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Veröffentlicht in:Chemical immunology and allergy 2005, Vol.89, p.10-25
Hauptverfasser: Laskarin, Gordana, Strbo, Natasa, Crncic, Tatjana Bogovic, Juretic, Koraljka, Bataille, Nathalie Ledee, Chaouat, Gerard, Rukavina, Daniel
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chapter
Cytokines - biosynthesis
Cytotoxicity, Immunologic
Female
Humans
Interleukin-15 - metabolism
Interleukin-18 - metabolism
Killer Cells, Natural - immunology
Maternal-Fetal Exchange - immunology
Models, Immunological
Pregnancy
Uterus - immunology
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Zusammenfassung:We review recent studies of two cytokines IL-15 and IL-18, showing that they are the critical cytokines controlling uterine NK cell cytokine production and cytolytic potential. Further, IL-15 has been implicated in differentiation and proliferation of uterine NK cells, while IL-18 enhanced innate immunity and both Th1- and Th2-driven immune responses depending on the cytokine milieu. We addressed the possible role of these two cytokines in induction of the IFN-γ production as a key molecule in vascular remodeling during early pregnancy.
ISSN:1660-2242
1662-2898
DOI:10.1159/000087906