Gastrointestinal Autonomic Nerve Tumor of the Colon: A Case Report with Immunohistochemical and Ultrastructural Studies

Gastrointestinal autonomic nerve tumor (GANT) is an uncommon subtype of gastrointestinal stromal tumor that is morphologically similar to conventional stromal tumors but has ultrastructural features of neural differentiation. Of the approximately 58 cases of GANT reported to date, most have arisen in the small intestine or stomach, but none, to our knowledge, in the colon or rectum. Accordingly, we report the first case of colonic GANT and document its histologic, ultrastructural, and immunohistochemical characteristics. These were not unlike those of GANT arising elsewhere in the alimentary tract, including interlacing spindle cells, skenoid fibers, axonal cytoplasmic processes, dense core neurosecretory granules, and immunoreactivity to vimentin and NSE. The rarity of GANT in the large intestine should not preclude ultrastructural evaluation of colorectal stromal tumors for neural features.